Cholestrol is synthesised in

Options

A. Brunner's glands
B. Liver
C. Spleen
D. Pancreas

Answer

### Step-by-Step Solution:

1. **Understanding Cholesterol Synthesis**: Cholesterol is a vital lipid molecule that is synthesized in the body. It plays important roles in cell membrane structure and serves as a precursor for steroid hormones and bile acids.

2. **Identifying the Primary Site of Synthesis**: The primary site of cholesterol synthesis in the body is the liver. While other organs may contribute to cholesterol levels, the liver is the main organ responsible for its production.

3. **Quantifying Cholesterol Production**: Approximately 50% of the cholesterol in the body is synthesized de novo (from scratch) in the liver. The liver accounts for about 10% of the total cholesterol produced daily, while the intestines contribute around 15%.

4. **Understanding the Biochemical Pathway**: The synthesis of cholesterol involves several enzymes located in the cytoplasm, endoplasmic reticulum, and peroxisomes. The process begins with the two-carbon acetate group derived from acetyl-CoA.

5. **Excluding Other Options**: The pancreas, spleen, and Brunner's glands do not synthesize cholesterol. Therefore, they can be ruled out as options for where cholesterol is synthesized.

6. **Conclusion**: Based on the information provided, the correct answer to the question "Cholesterol is synthesized in" is the liver.

### Final Answer:
Cholesterol is synthesized in the liver.

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