Which is not having high energy phosphate bond ?

Options

A. Creatine phosphate
B. GTP
C. ATP
D. AMP.

Answer

To determine which molecule does not have a high-energy phosphate bond among the options provided (creatine phosphate, GTP, ATP, AMP), we can analyze each option step by step.

### Step-by-Step Solution:

1. **Understanding High-Energy Phosphate Bonds**:
- High-energy phosphate bonds are typically found in molecules that can release significant energy upon hydrolysis. These bonds are usually present in triphosphate molecules or similar structures.

2. **Analyzing AMP (Adenosine Monophosphate)**:
- AMP consists of a ribose sugar, adenine, and one phosphate group. The bond between the ribose and the phosphate is an ester bond, which is not considered a high-energy bond. Therefore, AMP does not have a high-energy phosphate bond.

3. **Analyzing ATP (Adenosine Triphosphate)**:
- ATP has three phosphate groups. The bonds between the second and third phosphate groups (the terminal phosphate bond) are high-energy bonds. When ATP is hydrolyzed to ADP and inorganic phosphate, it releases a significant amount of energy.

4. **Analyzing GTP (Guanosine Triphosphate)**:
- GTP is similar to ATP and contains three phosphate groups. It also has high-energy phosphate bonds, particularly between the second and third phosphate groups. GTP can be hydrolyzed to GDP and inorganic phosphate, releasing energy.

5. **Analyzing Creatine Phosphate (Phosphocreatine)**:
- Creatine phosphate is a high-energy compound that can donate a phosphate group to ADP to form ATP. The bond between the phosphate group and creatine is a high-energy bond, allowing it to generate ATP during energy-demanding activities.

6. **Conclusion**:
- Among the options provided, AMP is the only molecule that does not have a high-energy phosphate bond. Therefore, the correct answer is **AMP**.