Pollutants, toxins and carcinogens are detoxified by

Options

A. `P_(450)` and `P_(448)`
B. S.E.R in liver
C. R.E.R in liver
D. Both A and B

Answer

### Step-by-Step Solution:

1. **Understanding the Question**: The question asks about the detoxification of pollutants, toxins, and carcinogens in the body. It is essential to identify which organelles or systems are responsible for this process.

2. **Identifying Key Organelles**: The primary organelle involved in detoxification is the **smooth endoplasmic reticulum (SER)**. The SER is responsible for various metabolic processes, including the detoxification of drugs and harmful substances.

3. **Role of Cytochromes**: Within the smooth endoplasmic reticulum, specific enzymes known as **cytochromes** (notably **cytochrome P450 and P448**) play a crucial role in the detoxification process. These enzymes help metabolize and eliminate toxins and carcinogens from the body.

4. **Function of the Smooth Endoplasmic Reticulum**: The smooth endoplasmic reticulum is not only involved in detoxification but also in the synthesis of lipids and steroids. However, its detoxification capability is particularly important for processing harmful substances.

5. **Conclusion**: Therefore, both the smooth endoplasmic reticulum and cytochromes (P450 and P448) are essential for the detoxification of pollutants, toxins, and carcinogens in the body. The liver cells, which are heavily involved in detoxification, have a high concentration of smooth endoplasmic reticulum.

### Final Answer:
Pollutants, toxins, and carcinogens are detoxified by the **smooth endoplasmic reticulum** and **cytochromes P450 and P448**.

---