Chloramphenicol prevents protein synthesis over

Options

A. Procaryotic ribosomes
B. Organelle ribosomes
C. Both A and B
D. 80 S ribosomes

Answer

To solve the question "Chloramphenicol prevents protein synthesis over," we will analyze the options provided and the mechanism of action of chloramphenicol.

### Step-by-Step Solution:

1. **Understanding Chloramphenicol**:
- Chloramphenicol is an antibiotic that is primarily known for its ability to inhibit protein synthesis in bacteria.

2. **Identifying Ribosomal Structures**:
- Prokaryotic ribosomes are composed of a 70S structure, which includes a 50S and a 30S subunit.
- Eukaryotic ribosomes (often referred to as organorebosomes in the context of organelles) are larger, typically 80S, which includes a 60S and a 40S subunit.

3. **Mechanism of Action**:
- Chloramphenicol specifically binds to the 50S subunit of the prokaryotic ribosome.
- It inhibits the peptidyl transferase activity, which is crucial for protein synthesis.

4. **Analyzing the Options**:
- **Option A: Prokaryotic ribosomes** - Chloramphenicol acts on these ribosomes, preventing protein synthesis.
- **Option B: Organorebosomes** - While chloramphenicol primarily targets prokaryotic ribosomes, it can also affect the 70S ribosomes found in organelles like mitochondria and chloroplasts, which are similar to prokaryotic ribosomes.
- **Option C: Both A and B** - This option suggests that chloramphenicol affects both prokaryotic ribosomes and organorebosomes.
- **Option D: ATS ribosomes** - This option is not relevant as ATS ribosomes do not exist in this context.

5. **Conclusion**:
- Since chloramphenicol inhibits protein synthesis in both prokaryotic ribosomes and organorebosomes, the correct answer is **Option C: both A and B**.

### Final Answer:
**Option C: both A and B**

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