Which of the following is correct for the origin of lysosome (L) ?

Options

A. Endoplasmic reticulum-Golgi complex -Lysosomes
B. Nuclear membrane-Golgi complex -Lysosomes
C. Endoplasmic complex-Vacuoles -Lysosomes
D. Mitochondria-Golgi complex -lysosomes

Answer

To determine the correct origin of lysosomes, we need to analyze the process of their formation step by step.

### Step-by-Step Solution:

1. **Understanding Lysosome Formation**: Lysosomes are membrane-bound organelles that contain hydrolytic enzymes necessary for digestion within the cell. Their formation involves several cellular organelles.

2. **Identifying Key Organelles**: The primary organelles involved in the formation of lysosomes are:
- **Endoplasmic Reticulum (ER)**: Specifically, the rough endoplasmic reticulum (RER) is where the precursor enzymes for lysosomes are synthesized.
- **Golgi Complex**: After synthesis in the RER, these precursor enzymes are transported to the Golgi complex, where they undergo modifications and are packaged into vesicles.

3. **The GERL Complex**: The formation of lysosomes is often referred to in the context of the GERL complex, which stands for:
- **G**olgi
- **E**ndosomes
- **R**ough Endoplasmic Reticulum
- **L**ysosomes

4. **Process of Lysosome Formation**:
- The precursor enzymes are synthesized in the RER.
- They are then sent to the Golgi complex, where they are modified and packaged.
- The Golgi complex pinches off vesicles containing these enzymes, which then fuse with endosomes.
- The fusion of these vesicles with endosomes leads to the formation of lysosomes.

5. **Evaluating the Options**: Now, we can evaluate the options provided in the question:
- **Option 1**: Endoplasmic Reticulum, Golgi Complex, Lysosome (Correct)
- **Option 2**: Nuclear Membrane, Golgi Complex, Lysosome (Incorrect)
- **Option 3**: Endoplasmic Complex, Vacuole, Lysosome (Incorrect)
- **Option 4**: Mitochondria, Golgi Complex, Lysosome (Incorrect)

6. **Conclusion**: The correct answer is **Option 1: Endoplasmic Reticulum, Golgi Complex, Lysosome**.