Alkaptonurics excreate excess of

Options

A. Urine
B. Albumen
C. Malony caetic acid
D. Homogentisic acid

Answer

To solve the question regarding what alkaptonurics excrete in excess, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Alkaptonuria**: Alkaptonuria is a genetic disorder characterized by the inability to properly metabolize certain substances in the body. It is inherited in an autosomal recessive manner.

2. **Identifying the Cause**: The disorder is caused by a mutation in the gene responsible for producing the enzyme homogentisate 1,2-dioxygenase (HGD). This enzyme is crucial for the breakdown of homogentisic acid.

3. **Accumulation of Homogentisic Acid**: Due to the mutation, there is an accumulation of homogentisic acid in the body. This substance is not effectively metabolized, leading to its excess in the urine.

4. **Symptoms of Alkaptonuria**: One of the primary symptoms of alkaptonuria is the excretion of dark urine. When the urine stands, it turns black due to the oxidation of homogentisic acid.

5. **Conclusion**: Based on the above understanding, the correct answer to the question "Alkaptonurics excrete excess of" is **homogentisic acid**.

### Final Answer:
Alkaptonurics excrete excess of **homogentisic acid**.

---