A genomic mutation is the mutation involving

Options

A. Change in gene
B. Change in chromosomal structure
C. Change in the number of chromosomes
D. All the above

Answer

To answer the question "A genomic mutation is the mutation involving," we need to analyze the options provided and understand what a genomic mutation entails.

### Step-by-Step Solution:

1. **Understanding Genomic Mutation**:
- A genomic mutation refers to any change that occurs within the genome, which includes alterations in genes, chromosomal structures, or the number of chromosomes.

2. **Analyzing the Options**:
- **Option A: Change in gene**: This is correct. Genomic mutations can involve changes in the DNA sequence of a gene, which can occur through various mechanisms such as deletion, addition, inversion, or translocation.

- **Option B: Change in chromosomal structure**: This is also correct. If a segment of a chromosome is deleted or added, it alters the structure of the chromosome, leading to a genomic mutation.

- **Option C: Change in number of chromosomes**: This is correct as well. A change in the number of chromosomes, such as aneuploidy (where there is an addition or deletion of chromosomes), is a type of genomic mutation. For example, Down syndrome is caused by trisomy of chromosome 21, which is a change in chromosome number.

3. **Conclusion**:
- Since all three options (change in gene, change in chromosomal structure, and change in number of chromosomes) are correct, the correct answer is **Option D: All of the above**. This means that genomic mutations can involve changes in genes, chromosomal structures, and chromosome numbers.

### Final Answer:
A genomic mutation is the mutation involving **all of the above** (change in gene, change in chromosomal structure, change in number of chromosomes).

---