Cholchicine interferes in

Options

A. Spindle organisation
B. DNA replication
C. Chromosome condensation
D. Polyploidy

Answer

**Step-by-Step Solution:**

1. **Understanding Colchicine**: Colchicine is an alkaloid that is known for its effects on cell division. It is often referred to as a "mitotic poison" because it disrupts normal mitotic processes.

2. **Mechanism of Action**: Colchicine specifically binds to tubulin, which is a protein that makes up microtubules. Microtubules are essential components of the spindle apparatus that segregates chromosomes during cell division.

3. **Effect on Spindle Apparatus**: By binding to tubulin, colchicine inhibits the assembly of microtubules. This disruption prevents the formation of the spindle fibers that are necessary for proper chromosome alignment and segregation during mitosis.

4. **Impact on Cell Division**: As a result of this interference, cells cannot complete mitosis properly. The cell division process is arrested at the metaphase stage, where chromosomes are aligned in the middle of the cell but cannot be separated.

5. **Conclusion**: Based on the mechanism of action and the effects of colchicine, the correct answer to the question "Colchicine interferes in" is **spindle organization** (Option A).

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