Hamophilia is due to mutation in

Options

A. X and Y chromosomes
B. Y-chromosome
C. X-chromosome
D. Autosomal chromosome

Answer

### Step-by-Step Solution:

1. **Understanding Hemophilia**: Hemophilia is a genetic disorder that affects the body's ability to form blood clots. This can lead to excessive bleeding after injuries and can increase the risk of bleeding in joints and the brain.

2. **Inheritance Pattern**: Hemophilia is primarily inherited through an X-linked recessive pattern. This means that the gene responsible for hemophilia is located on the X chromosome, and males (who have one X and one Y chromosome) are more frequently affected than females (who have two X chromosomes).

3. **Identifying the Chromosome**: Given the options:
- X and Y chromosome
- Y chromosome
- X chromosome
- Autosomal chromosome

We need to identify which chromosome is responsible for hemophilia. Since hemophilia is an X-linked disorder, the correct answer must involve the X chromosome.

4. **Types of Hemophilia**:
- **Hemophilia A**: Caused by a mutation in the gene for clotting factor VIII.
- **Hemophilia B**: Caused by a mutation in the gene for clotting factor IX.
- **Hemophilia C**: A rarer form caused by a mutation in the gene for clotting factor XI.

5. **Conclusion**: Since hemophilia is caused by mutations in genes located on the X chromosome, the correct answer to the question "Hemophilia is due to mutation in" is the **X chromosome**.

### Final Answer:
Hemophilia is due to a mutation in the **X chromosome**.

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