Failure of separation of sister chromatids us

Options

A. Fusion
B. Nondisjucntion
C. Complementation
D. Interference

Answer

**Step-by-Step Solution:**

1. **Understanding Cell Division**:
- During cell division, specifically in mitosis and meiosis, sister chromatids are formed. These chromatids are identical copies of a chromosome that are joined together at a region called the centromere.

2. **Separation of Sister Chromatids**:
- In normal cell division, sister chromatids are supposed to separate during anaphase. This separation allows each new daughter cell to receive an identical set of chromosomes.

3. **Failure of Separation**:
- If sister chromatids fail to separate properly during anaphase, this results in an unequal distribution of chromosomes in the daughter cells. This phenomenon is termed as "non-disjunction."

4. **Identifying the Correct Term**:
- The question asks for the term that describes the failure of separation of sister chromatids. The options provided include:
- Fusion
- Non-disjunction
- Complementation
- Interference

5. **Analyzing the Options**:
- **Fusion**: This refers to the merging of two entities, which does not apply to the separation of chromatids. Therefore, it is incorrect.
- **Non-disjunction**: This is the correct term for the failure of sister chromatids to separate during cell division.
- **Complementation**: This term generally refers to genetic interactions and does not relate to the separation of chromatids, making it incorrect.
- **Interference**: This term is used in genetics to describe the effect of one crossover event on another, which is not relevant to the separation of sister chromatids.

6. **Conclusion**:
- Based on the analysis, the correct answer to the question is "non-disjunction," which specifically describes the failure of sister chromatids to separate during cell division.

**Final Answer**: Non-disjunction

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