Which one is a sex linked disorder?

Options

A. Sickle cell anamia
B. Albinism
C. Haemophilia
D. Phenylketonuria and hamophila

Answer

To determine which of the options is a sex-linked disorder, we can analyze each option step by step:

1. **Identify the first option: Sickle Cell Anemia**
- Sickle cell anemia is caused by a recessive mutant allele located on chromosome 11.
- It is characterized by the substitution of glutamic acid by valine at the 6th position of the beta-globin chain of hemoglobin.
- Since it is caused by a gene on an autosome (chromosome 11), it is classified as an autosomal recessive disorder.
- **Conclusion**: This option is incorrect.

2. **Identify the second option: Albinism**
- Albinism is a condition that results from a lack of melanin production in the skin, hair, and eyes.
- It is caused by multiple genes (polygenic inheritance) and is not linked to the sex chromosomes.
- Therefore, it is also classified as an autosomal disorder.
- **Conclusion**: This option is incorrect.

3. **Identify the third option: Hemophilia**
- Hemophilia is a disorder that affects the blood's ability to clot properly.
- It is caused by a recessive gene located on the X chromosome, making it a sex-linked disorder.
- The gene responsible for hemophilia controls the synthesis of a protein necessary for blood clotting.
- **Conclusion**: This option is correct.

4. **Identify the fourth option: Phenylketonuria (PKU)**
- Phenylketonuria is a metabolic disorder caused by a deficiency of the enzyme phenylalanine hydroxylase.
- It is inherited in an autosomal recessive manner, meaning it is not linked to the sex chromosomes.
- **Conclusion**: This option is incorrect.

Based on the analysis, the only sex-linked disorder among the options is **Hemophilia**.

**Final Answer**: Hemophilia is a sex-linked disorder.

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