If father is normal while mother is carrier of haemophilia

Options

A. All female offspring will be carriers
B. A male offspring has 50% chance of activ edisease
C. A female offspring has 50% chance of active dissease
D. All female offsrping will be normal

Answer

To solve the problem regarding the inheritance of hemophilia when the father is normal and the mother is a carrier, we can follow these steps:

### Step 1: Understand the Genetic Background
- Hemophilia is an X-linked recessive disorder. This means that the gene responsible for hemophilia is located on the X chromosome.
- Males have one X and one Y chromosome (XY), while females have two X chromosomes (XX).

### Step 2: Define the Genotypes
- The father, being normal, has the genotype XY (where X is normal).
- The mother, being a carrier of hemophilia, has the genotype XHX (where XH represents the normal allele and Xh represents the hemophilia allele).

### Step 3: Determine Possible Gametes
- The father can produce two types of gametes: X (normal) and Y (male).
- The mother can produce two types of gametes: XH (normal) and Xh (hemophilia carrier).

### Step 4: Create a Punnett Square
- Set up a Punnett square to visualize the possible combinations of offspring:

| | XH (from mother) | Xh (from mother) |
|-------|-------------------|-------------------|
| **X (from father)** | XXH (normal female) | XXh (carrier female) |
| **Y (from father)** | XYH (normal male) | XYh (hemophilic male) |

### Step 5: Analyze the Results
- From the Punnett square, we can see:
- Female offspring possibilities: XXH (normal female) and XXh (carrier female).
- Male offspring possibilities: XYH (normal male) and XYh (hemophilic male).
- Therefore, there is a 50% chance for male offspring to have hemophilia (XYh) and a 50% chance for female offspring to be carriers (XXh).

### Conclusion
- The final answer is that a male offspring has a 50% chance of having active hemophilia.

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