Fin the odd one out with respect to X-linkage

Options

A. Haemophilia
B. Myopia
C. Nephritis
D. Night blindness

Answer

To solve the question of finding the odd one out with respect to X-linkage, we can follow these steps:

### Step-by-Step Solution:

1. **Understand X-linkage**: X-linked disorders are genetic conditions that are caused by mutations in genes located on the X chromosome. These disorders can affect both males and females, but they often manifest differently due to the presence of two X chromosomes in females and one in males.

2. **List the Options**: The options provided are:
- Hemophilia
- Myopia
- Nephritis
- Night blindness

3. **Identify X-linked Disorders**:
- **Hemophilia**: This is a well-known X-linked disorder that affects blood clotting.
- **Myopia**: While primarily a refractive error of the eye, some studies suggest that myopia can have genetic components, but it is not typically classified as an X-linked disorder.
- **Nephritis**: This condition refers to inflammation of the kidneys and is not linked to the X chromosome.
- **Night blindness**: This is often associated with X-linked conditions, particularly in relation to certain types of retinitis pigmentosa.

4. **Determine the Odd One Out**:
- Hemophilia, night blindness, and potentially myopia (to a lesser extent) can be linked to X-linked inheritance. However, nephritis is not an X-linked disorder at all.
- Therefore, the odd one out with respect to X-linkage is **Nephritis**.

### Final Answer:
The odd one out with respect to X-linkage is **Nephritis**.