Which disease has failure of CI' transport mechanism

Options

A. Colour blindess
B. Huntington's chorea
C. Phenylketonuria
D. Cystic fibrosis

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks which disease is associated with the failure of the chloride transport mechanism. We are given four options: color blindness, Huntington's chorea, phenylketonuria, and cystic fibrosis.

2. **Analyzing Each Option**:
- **Color Blindness**: This is an inherited disorder affecting the ability to distinguish colors. It is related to the eyes and photoreceptors (cones) and does not involve chloride transport. Therefore, it is not the correct answer.
- **Huntington's Chorea**: This is a neurodegenerative disorder caused by the death of brain cells. It is not related to chloride transport mechanisms. Thus, this option is also incorrect.
- **Phenylketonuria (PKU)**: This is a metabolic disorder caused by the inability to metabolize the amino acid phenylalanine due to a lack of the enzyme phenylalanine hydroxylase. It does not involve chloride transport mechanisms, making this option incorrect as well.
- **Cystic Fibrosis**: This is a genetic disorder caused by a defect in the chloride channels, leading to the failure of chloride transport. It affects multiple organs, including the lungs and pancreas, making it the correct answer.

3. **Conclusion**: Based on the analysis, the disease that has a failure of the chloride transport mechanism is **Cystic Fibrosis**.

**Final Answer**: Cystic fibrosis.

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