Enzyme adenosine deaminase is deficient in genetic disorder

Options

A. Alzheimer's disease
B. Muscular dystrophy
C. SCID
D. Colour blindness

Answer

**Step-by-Step Solution:**

1. **Identify the Enzyme and Its Function:**
- The enzyme in question is adenosine deaminase (ADA).
- ADA is crucial for the metabolism of adenosine, which is important for the maturation of T lymphocytes, a type of white blood cell involved in the immune response.

2. **Understand the Genetic Disorder:**
- The genetic disorder associated with the deficiency of adenosine deaminase is called Severe Combined Immunodeficiency Disorder (SCID).
- SCID is characterized by a severe defect in both the T and B lymphocyte systems, leading to a significantly weakened immune system.

3. **Link Between ADA Deficiency and SCID:**
- When adenosine deaminase is deficient, the accumulation of toxic metabolites leads to the death of lymphocytes, particularly T cells.
- This results in the inability of the body to mount an effective immune response, which is the hallmark of SCID.

4. **Evaluate Other Options:**
- Other options like Alzheimer's disease, muscular dystrophy, and color blindness do not involve adenosine deaminase deficiency.
- Alzheimer's disease is a neurodegenerative disorder, muscular dystrophy affects muscle function, and color blindness is a genetic condition linked to the X chromosome.

5. **Conclusion:**
- Therefore, the correct answer to the question is that the enzyme adenosine deaminase is deficient in Severe Combined Immunodeficiency Disorder (SCID).

**Final Answer:**
- The enzyme adenosine deaminase is deficient in Severe Combined Immunodeficiency Disorder (SCID).

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