Hypervariable repeats sequences or variable number of tandem repeats (VNTR) are

Options

A. Introns of split genes
B. Minisatellites
C. Flanked by conserved restriction sites.
D. Both B and C

Answer

### Step-by-Step Text Solution:

1. **Understanding VNTR**: Variable Number of Tandem Repeats (VNTR) refers to specific locations in the genome where a short nucleotide sequence is repeated multiple times in a row. These sequences can vary in length among different individuals.

2. **Characteristics of VNTR**: VNTRs are characterized by their variability in the number of repeats. This means that while one person might have a certain number of repeats, another person might have more or fewer repeats at the same location in the genome.

3. **Location and Structure**: VNTRs are often found on many chromosomes and are organized as tandem repeats. This means that the repeated sequences are directly adjacent to each other.

4. **Flanking Regions**: VNTRs are typically flanked by conserved restriction sites. These are specific sequences in the DNA where restriction enzymes can cut. The presence of these sites is important for genetic analysis and DNA profiling.

5. **Classification of VNTRs**: VNTRs are also referred to as mini-satellites. They can be distinguished from other types of repetitive DNA sequences based on their length and structure.

6. **Conclusion**: Given the characteristics of VNTRs, the correct answer to the question is that they are mini-satellites flanked by conserved restriction sites, which corresponds to options B and C.

### Final Answer:
Variable Number of Tandem Repeats (VNTR) are mini-satellites flanked by conserved restriction sites (both B and C).

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