B-cells produce antibodies in respone to instruction received from

Options

A. Killer T-cells
B. Suppressor T-cells
C. Mast cells
D. Helper T-cells

Answer

To answer the question "B-cells produce antibodies in response to instruction received from," we can follow these steps:

### Step-by-Step Solution:

1. **Identify the Role of B-cells**:
- B-cells, also known as B-lymphocytes, are a type of white blood cell that plays a crucial role in the immune response, particularly in humoral immunity.

2. **Understand Antibody Production**:
- B-cells are responsible for producing antibodies. These antibodies are proteins that specifically bind to antigens (foreign substances) to help neutralize or eliminate them.

3. **Recognize the Interaction with Antigens**:
- When a B-cell encounters an antigen, it binds to it. This binding is essential for the activation of the B-cell.

4. **Identify the Role of T-helper Cells**:
- After binding to the antigen, B-cells require additional signals to fully activate. This is where T-helper cells come into play. T-helper cells provide the necessary signals (instructions) for B-cells to proliferate and differentiate into plasma cells.

5. **Differentiate Plasma Cells**:
- Once activated by T-helper cells, B-cells differentiate into plasma cells, which are specialized for producing large quantities of antibodies.

6. **Conclusion**:
- Therefore, B-cells produce antibodies in response to instructions received from T-helper cells.

### Final Answer:
B-cells produce antibodies in response to instructions received from **T-helper cells** (Option D).

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