Antibody which mediates allergic response is

Options

A. IgA
B. IgD
C. IgE
D. IgM

Answer

To determine which antibody mediates allergic responses, we can analyze the options provided:

1. **Understanding the Options**:
- **IgA**: This antibody is primarily found in mucosal areas, such as the gut and respiratory tract, and plays a role in mucosal immunity. It helps protect against infections but is not specifically involved in allergic reactions.
- **IgD**: This antibody is found on the surface of immature B lymphocytes and is involved in signaling these cells to activate. It does not play a significant role in mediating allergic responses.
- **IgE**: This antibody is specifically associated with allergic reactions and hypersensitivity. It is produced in response to allergens and binds to mast cells and basophils, leading to the release of histamine and other chemicals that cause allergic symptoms.
- **IgM**: This is the largest antibody and is primarily involved in the initial immune response to infections, particularly viral infections. It does not mediate allergic responses.

2. **Identifying the Correct Answer**:
- Based on the analysis, IgE is the antibody that is specifically involved in mediating allergic responses. It plays a crucial role in conditions such as allergic asthma, hay fever, food allergies, and other allergic reactions.

3. **Conclusion**:
- Therefore, the antibody that mediates allergic responses is **IgE**.