Clinical fever in malaria is due to

Options

A. Erythrocytic-gametogony
B. Erthrocytic schizogony
C. Pre-erythrocytic schizogony
D. Exo-erythrocytic schizogony

Answer

### Step-by-Step Solution:

1. **Understanding Malaria**: Malaria is a disease caused by the Plasmodium parasite, which is transmitted to humans through the bite of infected female Anopheles mosquitoes.

2. **Life Cycle of Plasmodium**: The life cycle of Plasmodium has two main phases: asexual and sexual. The asexual phase occurs in humans, while the sexual phase occurs in mosquitoes.

3. **Infection Process**: When an infected female Anopheles mosquito bites a human, it injects sporozoites into the bloodstream. These sporozoites travel to the liver.

4. **Exoerythrocytic Phase**: The entry of sporozoites into the liver is known as the exoerythrocytic phase. During this phase, the sporozoites mature but do not cause fever.

5. **Erythrocytic Phase**: After maturing in the liver, the parasite transforms into merozoites, which then enter the bloodstream and invade red blood cells (RBCs). This invasion is known as erythrocytic schizogony.

6. **Fever Symptoms**: The destruction of red blood cells during the erythrocytic phase leads to the release of toxins and other substances into the bloodstream, which triggers the immune response and results in clinical fever.

7. **Conclusion**: Therefore, the clinical fever in malaria is primarily due to the erythrocytic schizogony phase, where the merozoites invade and destroy red blood cells.

### Final Answer:
The clinical fever in malaria is due to the erythrocytic schizogony phase of the Plasmodium life cycle.

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