During infection T-cells interact with

Options

A. Macrophages
B. B-cells
C. Infected cells
D. Erythrocytes

Answer

**Step-by-Step Solution:**

1. **Understanding T-Cells**: T-cells are a type of white blood cell that play a crucial role in the immune response. They are primarily involved in recognizing and responding to antigens presented by other cells.

2. **Identifying Interaction Partners**: During an infection, T-cells interact with various types of cells. The options provided are:
- Macrophages
- B-cells
- Infected cells
- Erythrocytes

3. **Role of B-Cells**: B-cells are responsible for producing antibodies. They have receptors that can bind to specific antigens. Once they bind to an antigen, they can internalize it through a process called receptor-mediated endocytosis.

4. **Antigen Presentation**: After engulfing the antigen, B-cells process it and present it on their surface using Major Histocompatibility Complex class II (MHC-II) molecules. This is crucial for T-cell activation.

5. **T-Cell Activation**: T-cells recognize the antigen-MHC-II complex on the B-cells. This interaction is essential for the activation of T-cells, which then secrete lymphokines (a type of signaling molecule).

6. **B-Cell Proliferation**: The lymphokines released by T-cells stimulate B-cells to proliferate and differentiate into plasma cells that produce antibodies specific to the antigen.

7. **Conclusion**: Based on the interactions described, during an infection, T-cells primarily interact with B-cells to facilitate the immune response.

**Final Answer**: T-cells interact with B-cells during infection.

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