Transformation of a normal cell to cancer cell may start with changes in

Options

A. Cytoplasm
B. Nucleus
C. Mitochondria
D. Fibronectin

Answer

To answer the question regarding the transformation of a normal cell to a cancer cell, we need to understand the underlying mechanisms involved in this process. Here’s a step-by-step breakdown of the solution:

### Step-by-Step Solution:

1. **Understanding Cancer Development**:
- Cancer is primarily caused by mutations in genes that regulate cell growth and division. These mutations can lead to uncontrolled cell proliferation or halt the normal cell cycle.

2. **Identifying the Location of Genes**:
- Genes, which are the basic units of heredity, are composed of DNA. This DNA is located within the nucleus of the cell.

3. **Role of the Nucleus**:
- The nucleus is the control center of the cell, housing the genetic material (DNA). Changes or mutations in the genes located in the nucleus can initiate the transformation of a normal cell into a cancerous cell.

4. **Evaluating the Options**:
- The options provided were:
- A) Cytoplasm
- B) Nucleus
- C) Mitochondria
- D) Fibronectin
- Among these, the nucleus is the only option where genetic mutations can occur that lead to cancer.

5. **Conclusion**:
- Therefore, the transformation of a normal cell to a cancer cell may start with changes in the **nucleus**.

### Final Answer:
The correct answer is **B) Nucleus**.