Which of the following diseases is not treated by inactivated Whole Agent Vaccine

Options

A. Hepatitis -A
B. Bubonic plague
C. Cholera
D. Typhoid

Answer

To solve the question "Which of the following diseases is not treated by inactivated Whole Agent Vaccine?" we will analyze each option provided.

### Step-by-Step Solution:

1. **Understand the Types of Vaccines**:
- Inactivated Whole Agent Vaccines are made from pathogens that have been killed or inactivated so they cannot cause disease. They stimulate an immune response without causing the disease.

2. **List the Options**:
- The diseases mentioned are:
- Hepatitis A
- Bubonic plague
- Cholera
- Typhoid

3. **Identify the Nature of Each Disease**:
- **Hepatitis A**: This is a viral infection and is treated with an inactivated whole agent vaccine.
- **Bubonic plague**: This is caused by the bacterium Yersinia pestis and can be treated with an inactivated vaccine.
- **Cholera**: This is caused by the bacterium Vibrio cholerae and is also treated with an inactivated whole agent vaccine.
- **Typhoid**: This is caused by the bacterium Salmonella typhi. Historically, there was an inactivated whole cell vaccine for typhoid, but it is no longer widely used due to side effects and the availability of better alternatives.

4. **Determine the Odd One Out**:
- While all the other diseases (Hepatitis A, Bubonic plague, and Cholera) have effective inactivated whole agent vaccines, the typhoid vaccine is not commonly used anymore due to its adverse effects and the development of more effective vaccines.

5. **Conclusion**:
- Therefore, the disease that is not treated by an inactivated Whole Agent Vaccine is **Typhoid**.

### Final Answer:
**Typhoid**