Which of the following is not correct with respect to malaria

Options

A. Malignant malaria is caused by Plasmodium falciparum
B. Female Anopheles mosquito is the vector
C. Sporozoites multiply in blood
D. RBCs rupture and release haemizoin which causes chills

Answer

To determine which statement is not correct with respect to malaria, we will analyze each option provided in the question.

### Step-by-Step Solution:

1. **Understand Malignant Malaria**:
- Malignant malaria is indeed caused by *Plasmodium falciparum*. This species is known for causing severe forms of malaria, which can lead to high mortality rates.
- **Conclusion**: This statement is correct.

2. **Identify the Vector**:
- The female *Anopheles* mosquito is the known vector for malaria. It is responsible for transmitting the *Plasmodium* parasite to humans through its bite.
- **Conclusion**: This statement is also correct.

3. **Sporozoite Multiplication**:
- Sporozoites are the infective form of the *Plasmodium* parasite that enter the human body through the mosquito bite. However, they do not multiply in the blood. Instead, they travel to the liver where they multiply and develop into merozoites.
- **Conclusion**: This statement is incorrect, as sporozoites do not multiply in the blood.

4. **RBC Rupture and Hemozoin**:
- When the merozoites invade red blood cells (RBCs), the rupture of these cells releases hemozoin, a byproduct of hemoglobin digestion. This release is associated with the chills and fever characteristic of malaria.
- **Conclusion**: This statement is correct.

### Final Answer:
The statement that is not correct with respect to malaria is: **"Sporozoites multiply in blood."**

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