Which of the following genetic diseases show criss-cross pattern of inheritance?

Options

A. haemophilia and colour blindness
B. haemophilia, colour blindness and hypertrichosis of ear
C. albinism and sickle cell anaemia
D. Klinefelter's syndrome and Turner's syndrome

Answer

To determine which genetic diseases show a criss-cross pattern of inheritance, we need to understand the concept of criss-cross inheritance and identify the diseases mentioned in the question.

### Step-by-Step Solution:

1. **Understanding Criss-Cross Inheritance**:
- Criss-cross inheritance refers to the pattern where a genetic trait is passed from a parent to their offspring in a way that the trait can skip generations or be expressed in a different gender than the parent. Specifically, in sex-linked traits, this often means that a mother can pass a trait to her son, and a father can pass it to his daughter.

2. **Identifying Sex-Linked Disorders**:
- The question lists several genetic diseases: hemophilia, color blindness, hypotrichosis of the ear, albinism, sickle cell anemia, Klinefelter syndrome, and Turner syndrome.
- Hemophilia and color blindness are known to be sex-linked recessive disorders. This means they are carried on the X chromosome and can show criss-cross inheritance.

3. **Analyzing Each Disease**:
- **Hemophilia**: A recessive disorder linked to the X chromosome. A carrier mother can pass the affected X chromosome to her son, resulting in hemophilia in the son.
- **Color Blindness**: Similar to hemophilia, it is also a recessive disorder linked to the X chromosome and shows the same inheritance pattern.
- **Hypotrichosis of the Ear**: This is a Y-linked trait, meaning it is passed from father to son, not showing criss-cross inheritance.
- **Albinism**: An autosomal recessive disorder, not linked to sex chromosomes, thus does not show criss-cross inheritance.
- **Sickle Cell Anemia**: This is an autosomal recessive disorder, not sex-linked, so it does not show criss-cross inheritance.
- **Klinefelter Syndrome and Turner Syndrome**: These are chromosomal disorders and do not exhibit criss-cross inheritance.

4. **Conclusion**:
- The diseases that show a criss-cross pattern of inheritance are **hemophilia and color blindness**.

### Final Answer:
The genetic diseases that show a criss-cross pattern of inheritance are **hemophilia and color blindness**.