Which ONE of the following statements is INCORRECT about the hexokinase-catalysed reaction given below ? Glucose + ATP ` to` Glucose-6-phosphate+ADP

Options

A. This reaction takes place in the cytoplasm
B. This is an endergonic reaction
C. Folding of hexokinase to fit around the glucose molecule excludes water from the active site
D. This reaction involves an induced fit mechanism in hexokinase

Answer

To determine which statement is incorrect about the hexokinase-catalyzed reaction of glucose and ATP to form glucose-6-phosphate and ADP, we will analyze each statement related to the reaction.

### Step-by-Step Solution:

1. **Understanding the Reaction**:
- The reaction is:
\[ \text{Glucose} + \text{ATP} \rightarrow \text{Glucose-6-phosphate} + \text{ADP} \]
- This reaction is part of the glycolysis pathway.

2. **Analyzing Each Statement**:
- **Statement 1**: "This reaction takes place in the cytoplasm."
- **Analysis**: Glycolysis, including the hexokinase reaction, occurs in the cytoplasm. This statement is correct.

- **Statement 2**: "This is an endergonic reaction."
- **Analysis**: An endergonic reaction requires energy input, meaning the products have higher free energy than the reactants. However, this reaction releases energy because ATP is hydrolyzed, making it an exergonic reaction. This statement is incorrect.

- **Statement 3**: "Folding of hexokinase to feed around the glucose molecule excludes water from the active site."
- **Analysis**: This is correct as the enzyme hexokinase folds around glucose to facilitate the reaction and minimize the presence of water at the active site, which can interfere with the binding.

- **Statement 4**: "This reaction involves an induced fit mechanism in hexokinase."
- **Analysis**: The induced fit model describes how an enzyme changes shape to better fit the substrate upon binding. This is a correct description of how hexokinase functions.

3. **Conclusion**:
- The incorrect statement about the hexokinase-catalyzed reaction is **Statement 2**, which claims that the reaction is endergonic.

### Final Answer:
The incorrect statement is: "This is an endergonic reaction."