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Why is sickle celled anaemia called mole...

Why is sickle celled anaemia called molecular disease ?

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It is called a molecular disease because of formation of abnormal haemoglobin Hb-s due to defective gene Hos. Hb-S differs from normal HB-A in only one amino acid (6th amino acid in `beta` chain) where glutamic acid is replaced by valine due to substitution (Transversion).
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BETTER CHOICE PUBLICATION-PRINCIPLES OF INHERITANCE AND VARIATION -LONG ANSWER TYPE QUESTIONS
  1. Why is sickle celled anaemia called molecular disease ?

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  2. State and explain Mendel's law of independent assortment with the help...

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  3. Describe quantitative inheritance taking skin colour of man as an exam...

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  4. What do you understand and by chromosonal disorder? Explain it with th...

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  5. Explain Mendel’s law of segregation with the help of a monohybrid cros...

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  6. Why did mendel choose garden pea for his experiments?

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  7. How did Mendel make sure that the plants were true breeding?

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  8. What are complementary genes? Give one example. Explain their interact...

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  9. Define crossing over. Explain its types. Also discuss its mechanism.

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  10. Define mutation.

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  11. Describe in detail chromosomal mutations.

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  12. Define pleiotropy.Explain pleiotropy with suitable example.

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  13. What are induced mutations ? Write about physical and chemical mutagen...

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  14. Describe chemical and physical mutagens to bring about mutations.

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  15. Define gene mutation

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  16. Explain in detail about the types of gene mutations.

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  17. Give two reasons why Mendel chose garden pea for his experiments? Give...

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  18. List any four symptoms of Down's syndrome. What is the basis of this d...

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  19. Study the given pedigree chart and answer the questions that follow. ...

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  20. Study the given pedigree chart and answer the questions that follow. ...

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  21. Study the given pedigree chart and answer the questions that follow. ...

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