Which of the following will give Hofmann-Bromoamide reaction?

Options

A.
B.
C.
D.

Explanation

To determine which of the given compounds will undergo the Hofmann-Bromoamide reaction, we need to understand the nature of the compounds involved in this reaction. The Hofmann-Bromoamide reaction is a chemical reaction that converts primary amides into primary amines with the loss of one carbon atom. This reaction requires specific reagents, which are bromine (Br2) in the presence of a strong base such as potassium hydroxide (KOH) or sodium hydroxide (NaOH).

### Step-by-Step Solution:

1. **Identify the Reaction Requirements**:
- The Hofmann-Bromoamide reaction requires a primary amide as the starting material.
- The reagents used are bromine (Br2) and a strong base (KOH or NaOH).

2. **Understand the Structure of Primary Amides**:
- A primary amide has the general structure R-C(=O)-NH2, where R is a hydrocarbon group.
- The nitrogen in primary amides is attached to only one carbon atom.

3. **Analyze Each Option**:
- **Option A**: Check if it is a primary amide.
- If it has the structure R-C(=O)-NH2, then it can undergo the Hofmann-Bromoamide reaction.
- **Option B**: Check if it is a primary amide.
- If it has a phenyl group (C6H5) attached to the carbonyl carbon, it is still a primary amide and can undergo the reaction.
- **Option C**: Check if it is a primary amide.
- If it fits the structure of a primary amide, it can also undergo the reaction.
- **Option D**: Check if it is a primary amide.
- If the nitrogen is attached to two carbon atoms (making it a secondary amine), it cannot undergo the Hofmann-Bromoamide reaction.

4. **Conclusion**:
- After analyzing all options:
- **Option A**: Primary amide → Yes, it can undergo the reaction.
- **Option B**: Primary amide (phenyl group) → Yes, it can undergo the reaction.
- **Option C**: Primary amide → Yes, it can undergo the reaction.
- **Option D**: Secondary amine → No, it cannot undergo the reaction.
- Therefore, the compounds that will give the Hofmann-Bromoamide reaction are **Option A, Option B, and Option C**.

### Final Answer:
The correct options that will give the Hofmann-Bromoamide reaction are **Option A, Option B, and Option C**.