Facilitated diffusion and active transport both are affected by inhibitors those react with protein side chain of transporters.

Answer

**Step-by-Step Solution:**

1. **Understanding Transport Mechanisms:**
- There are three main types of transport mechanisms in biological systems: diffusion, facilitated diffusion, and active transport.
- Diffusion occurs naturally and does not require energy or a living system, while facilitated diffusion and active transport require specific proteins and energy, respectively.

2. **Facilitated Diffusion:**
- Facilitated diffusion is a passive transport mechanism that uses protein channels or carriers to help move substances across the cell membrane.
- This process does not require energy as it relies on the concentration gradient.

3. **Active Transport:**
- Active transport, on the other hand, is an energy-dependent process that moves substances against their concentration gradient.
- This process is mediated by specific transport proteins, such as sodium-potassium pumps, which require ATP to function.

4. **Role of Inhibitors:**
- Inhibitors can affect both facilitated diffusion and active transport by interacting with the transport proteins.
- These inhibitors often act as protein poisons that can denature the proteins, disrupting their function.

5. **Mechanism of Inhibition:**
- The inhibitors react with the side chains of amino acids in the protein structure of transporters.
- This reaction can lead to a loss of function of the transport proteins, thereby reducing the rate of transport across the membrane.

6. **Conclusion:**
- Therefore, both facilitated diffusion and active transport are indeed affected by inhibitors that react with the protein side chains of transporters, leading to decreased transport efficiency.