The stage of mitosis in which splitting of centromeres occurs-

Answer

**Step-by-Step Text Solution:**

1. **Understanding Centromeres**: Centromeres are the regions on chromosomes where sister chromatids are joined together. They play a crucial role during cell division.

2. **Identifying Mitosis Stages**: Mitosis consists of several stages: prophase, metaphase, anaphase, and telophase. Each stage has specific events that occur.

3. **Focus on Anaphase**: The question specifically asks about the stage where the splitting of centromeres occurs. This event takes place during anaphase.

4. **Role of Spindle Fibers**: During anaphase, spindle fibers, which are structures formed from the centrioles, attach to the kinetochores located at the centromeres of the chromosomes.

5. **Splitting of Sister Chromatids**: Once the spindle fibers are attached, they begin to pull the sister chromatids apart towards opposite poles of the cell. This pulling action leads to the splitting of the centromeres.

6. **Conclusion**: Therefore, the stage of mitosis in which the splitting of centromeres occurs is **anaphase**.

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