AIDS is characterized by reduction in

Options

A. Mast cells
B. neutrophils
C. RBC
D. Helper T-cells

Answer

**Step-by-Step Solution:**

1. **Understanding AIDS**: AIDS stands for Acquired Immunodeficiency Syndrome. It is caused by the Human Immunodeficiency Virus (HIV), which is an RNA virus.

2. **Mechanism of HIV Infection**: The virus initially attacks macrophages, which are a type of immune cell. After multiplying within these cells, the virus is released into the bloodstream.

3. **Targeting T Helper Cells**: The HIV virus specifically targets T helper cells (also known as CD4+ T cells). These cells are crucial for the immune response as they help activate other immune cells.

4. **Destruction of T Helper Cells**: Once HIV enters T helper cells, it replicates and eventually causes the rupture of these cells. This leads to a significant reduction in the number of T helper cells in the body.

5. **Impact on Immunity**: The reduction in T helper cells severely compromises the immune system. Since T helper cells are essential for cell-mediated immunity, their loss means the body becomes vulnerable to opportunistic infections.

6. **Consequences of Reduced T Helper Cells**: With a weakened immune system, individuals with AIDS are susceptible to various infections, including tuberculosis, candidiasis, and other opportunistic infections, which can ultimately lead to death.

7. **Conclusion**: Therefore, AIDS is characterized by a drastic reduction in T helper cells.

**Final Answer**: T helper cells.

---