Prophase is marked by :

Options

A. The initiation of condensation of chromosomal material
B. DNA Dupltication
C. Transcription and translation
D. Duplication of centriole

Answer

To answer the question "Prophase is marked by:", we will analyze the options provided and determine which one correctly describes a key event that occurs during prophase in mitosis.

### Step-by-Step Solution:

1. **Understanding Prophase**: Prophase is the first stage of mitosis, which is the process of cell division that results in two identical daughter cells.

2. **Analyzing the Options**:
- **Option 1: Initiation of condensation of chromosomal material**: During prophase, chromatin (the complex of DNA and proteins) condenses into visible chromosomes. This is a defining feature of prophase.
- **Option 2: DNA duplication**: DNA duplication occurs during the S phase of interphase, not during prophase.
- **Option 3: Transcription and translation**: These processes occur during interphase, not specifically during prophase.
- **Option 4: Duplication of centriole**: While centrioles do duplicate during the cell cycle, this occurs prior to prophase during interphase.

3. **Conclusion**: The key event that marks prophase is the initiation of the condensation of chromosomal material. Therefore, the correct answer is **Option 1**.

### Final Answer:
**Prophase is marked by the initiation of condensation of chromosomal material. (Option 1)**

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