Which is not a correct match :-

Options

A. Deletion-Loss of a segment of DNA result in alteration in chromosome
B. Insertion - Gain of a segment of DNA, result in alteration in chromosome
C. Aberration -Result of chromosomal alteration
D. Sickle cell anemia - A classical example of frame shift mutation

Answer

To determine which statement is not a correct match, we will analyze each option provided in the question.

1. **Deletion**: This refers to the loss of a segment of DNA, which indeed results in an alteration in the chromosome. This statement is correct.

2. **Insertion**: This indicates the gain of a segment of DNA, which also results in an alteration in the chromosome. This statement is correct as well.

3. **Aberration**: This term refers to chromosomal alterations, which can include various structural changes in chromosomes. This statement is also correct.

4. **Sickle Cell Anemia**: The statement claims that sickle cell anemia is a classical example of a frameshift mutation. However, sickle cell anemia is actually a classical example of a point mutation, where a single nucleotide change leads to the production of abnormal hemoglobin. Therefore, this statement is incorrect.

Based on the analysis, the option that is not a correct match is:

**Sickle Cell Anemia - a classical example of frameshift mutation.**

### Step-by-Step Solution:
1. **Identify the terms**: Understand the terms involved - deletion, insertion, aberration, and sickle cell anemia.
2. **Analyze each option**: Evaluate whether each statement correctly describes the relationship between the term and its definition.
3. **Determine correctness**: Identify which statement is incorrect based on the definitions and examples of mutations.
4. **Conclude**: State which option is not a correct match.