Which is incorrect statement :-

Options

A. The process of translation required transfer of genetic information from a polymer of nucleotides to a polymer of amino acid
B. According to Goerge Gamow codon was a doublet
C. The chemical method developed by Har Gobind Khorana was instrumental in synthesising RNA molecules with defined
combinations of bases
D. Severo ochoa enzyme (polynucleotide phosphorylase) helpful in polymerising RNA with defined sequences in a template
independent manner

Answer

To determine which statement is incorrect, we will analyze each statement one by one.

### Step-by-Step Solution:

1. **Statement 1**: "The process of translation requires transfer of genetic information from a polymer of nucleotides to a polymer of amino acids."
- **Analysis**: This statement is correct. In translation, the information encoded in mRNA (a polymer of nucleotides) is used to synthesize proteins (polymers of amino acids). Therefore, this statement is true.

2. **Statement 2**: "According to George Gamow, codon was doublet."
- **Analysis**: This statement is incorrect. George Gamow proposed that codons are triplets, not doublets. Therefore, this statement is false.

3. **Statement 3**: "The chemical method developed by Hargobind Khurana was instrumental in synthesizing RNA molecules with defined combination of bases."
- **Analysis**: This statement is correct. Hargobind Khurana developed methods to synthesize RNA with specific sequences, which helped in understanding the genetic code. Hence, this statement is true.

4. **Statement 4**: "Severo Ochoa enzyme polynucleotide phosphorylase helpful in polymerizing RNA with defined sequences in a template independent manner."
- **Analysis**: This statement is also correct. Severo Ochoa discovered polynucleotide phosphorylase, which can synthesize RNA without a DNA template. Thus, this statement is true.

### Conclusion:
The incorrect statement is **Statement 2**: "According to George Gamow, codon was doublet."

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