Sickle cell anaemia is an example of :-

Options

A. Frame shift mutation
B. Point mutation
C. Segmental mutation
D. Gibberish mutation

Answer

**Step-by-Step Solution:**

1. **Understanding Sickle Cell Anemia**: Sickle cell anemia is a genetic disorder that affects the shape and function of red blood cells. It is important to identify the type of mutation responsible for this condition.

2. **Identifying Mutation Types**: The options provided are:
- Frameshift mutation
- Point mutation
- Segmental mutation
- Gibberish mutation

3. **Defining Point Mutation**: A point mutation is a change in a single nucleotide base pair in DNA. This can occur as a transition (purine to purine or pyrimidine to pyrimidine) or a transversion (purine to pyrimidine or vice versa).

4. **Analyzing the Mutation in Sickle Cell Anemia**: In sickle cell anemia, a specific point mutation occurs in the beta-globin gene of hemoglobin. The codon GAG, which codes for the amino acid glutamic acid, is mutated to GUG, which codes for valine.

5. **Conclusion**: Since sickle cell anemia is caused by a single nucleotide change (point mutation) that results in a different amino acid being incorporated into the hemoglobin protein, it is classified as a point mutation.

6. **Final Answer**: Therefore, the correct answer is that sickle cell anemia is an example of a **point mutation**.

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