A class of mutation induced by addition or deletion of a nucleotide is called :-

Options

A. Missense
B. Non-sense
C. Substitution
D. frame shift

Answer

To solve the question regarding the class of mutation induced by the addition or deletion of a nucleotide, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Types of Mutations**:
- There are various types of mutations that can occur in DNA. It's important to know the definitions of each type to identify the correct answer.

2. **Identify the Options**:
- The options given are:
- A) Missense
- B) Nonsense
- C) Substitution
- D) Frameshift

3. **Define Each Option**:
- **Missense Mutation**: This is a mutation that results in a single amino acid change in the protein sequence due to a change in one base pair.
- **Nonsense Mutation**: This type of mutation introduces a premature stop codon in the protein sequence, leading to a truncated protein.
- **Substitution Mutation**: This involves replacing one base pair with another, which may or may not affect the amino acid sequence.
- **Frameshift Mutation**: This occurs when one or more nucleotides are added or deleted from the DNA sequence, causing a shift in the reading frame of the codons.

4. **Analyze the Question**:
- The question specifically asks for a mutation caused by the addition or deletion of a nucleotide.

5. **Select the Correct Answer**:
- Based on the definitions, the addition or deletion of a nucleotide directly leads to a frameshift mutation, as it alters the reading frame of the genetic code.

6. **Conclusion**:
- Therefore, the correct answer to the question is **D) Frameshift**.