Assertion :- Positively charged histone proteins are essential for packaging negatively charged DNA.
Reason : Without histone protein DNA can not fold due to negative charge.

Options

A. If both Assertion & Reason are True & the Reason is a correct explanation of the Assertion.
B. If both Assertion & Reason are trur but Reason is not a correct explanation of the Assertion.
C. If Assertion is True but the Reason is Flase.
D. If both Assertion & Reason are false.

Answer

### Step-by-Step Solution:

1. **Understanding the Assertion**: The assertion states that positively charged histone proteins are essential for packaging negatively charged DNA. This is true because histones are basic proteins that have a positive charge due to their amino acid composition.

2. **Understanding the Reason**: The reason provided states that without histone proteins, DNA cannot fold due to its negative charge. This is also true because the negative charge of DNA (due to its phosphate backbone) would lead to repulsion between DNA strands, making it difficult for DNA to condense or fold without the presence of positively charged histones.

3. **Combining the Concepts**: When histone proteins bind to DNA, they neutralize the negative charges on the DNA, allowing for the formation of a nucleosome. This is a fundamental unit of chromatin, where DNA is wrapped around histone proteins, facilitating the compact packaging of DNA within the nucleus.

4. **Conclusion on Truthfulness**: Both the assertion and the reason are true statements. Moreover, the reason correctly explains why the assertion is true. Therefore, the relationship between the assertion and reason is that the reason provides a valid explanation for the assertion.

5. **Final Answer**: Since both the assertion and reason are true, and the reason is the correct explanation of the assertion, the answer is that both the assertion and reason are true, and the reason is the correct explanation of the assertion.