Which of the following is correct match
`{:(,"Column I",,"Column II"),(A,ADA-"deficiency",i,alpha -1 "antitrypsin"),(B,"Emphysema",ii,"Bone marrow transplantion"),(C,"Insulin",iii,"Diabetes mellitus"),(D,"Insect resistance",iv,T_(1) -"plasmid"):}`

Options

A. A(ii), B(i), C(iii), D(iv)
B. A(i), B(ii), C(iii), D(iv)
C. A(iii), B(iv), C(ii), D(i)
D. A(iv), B(iii), C(ii), D(i)

Answer

To solve the question regarding the correct matches between Column I and Column II, we will analyze each option step by step.

### Step 1: Analyze ADA Deficiency
- **ADA Deficiency** (A) is a condition also known as Severe Combined Immunodeficiency (SCID). It is caused by a deficiency in the enzyme adenosine deaminase.
- The permanent treatment for ADA deficiency is **Bone Marrow Transplantation** (ii).

**Match**: A → ii

### Step 2: Analyze Emphysema
- **Emphysema** (B) is a lung condition characterized by damage to the alveoli, often due to smoking.
- It can be treated with **alpha-1 antitrypsin**, which is produced using recombinant DNA technology (i).

**Match**: B → i

### Step 3: Analyze Insulin
- **Insulin** (C) is a hormone essential for regulating blood glucose levels, and it is commonly associated with **Diabetes Mellitus** (iii).

**Match**: C → iii

### Step 4: Analyze Insect Resistance
- **Insect Resistance** (D) can be achieved through the use of **T1 plasmid** (iv), which is a type of plasmid used in genetic engineering, particularly with the bacterium Agrobacterium tumefaciens.

**Match**: D → iv

### Final Matches
Now, we can summarize the matches:
- A → ii (ADA Deficiency → Bone Marrow Transplantation)
- B → i (Emphysema → Alpha-1 Antitrypsin)
- C → iii (Insulin → Diabetes Mellitus)
- D → iv (Insect Resistance → T1 Plasmid)

Thus, the correct order of matches is:
- A: 2
- B: 1
- C: 3
- D: 4

### Conclusion
The correct answer is **A: 2, B: 1, C: 3, D: 4**.

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