Kidney function is regulated by feedback mechanism involving the _____ and _____

Answer

**Step-by-Step Solution:**

1. **Understanding Kidney Function**: The kidneys are vital organs responsible for filtering blood, removing waste, and regulating various bodily functions, including fluid balance, electrolytes, and blood pressure.

2. **Feedback Mechanism**: The regulation of kidney function is primarily controlled through feedback mechanisms. This means that the body monitors the levels of various substances and adjusts kidney activity accordingly to maintain homeostasis.

3. **Identifying Key Components**: Two critical components involved in the feedback regulation of kidney function are:
- **Hypothalamus**: This part of the brain plays a crucial role in maintaining homeostasis. It regulates thirst, fluid balance, and can influence kidney function through hormones.
- **Juxtaglomerular Apparatus**: This structure is located near the glomerulus of the nephron and is involved in regulating blood pressure and the filtration rate of the kidneys by releasing renin in response to low blood pressure.

4. **Final Answer**: Therefore, the blanks in the question can be filled as follows: "Kidney function is regulated by feedback mechanism involving the **hypothalamus** and **juxtaglomerular apparatus**."

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