Substance which are not related with hepatic portal circulation `:-`

Options

A. Amino acid
B. Fatty acid
C. Glucose
D. Fructose

Answer

**Step-by-Step Solution:**

1. **Understanding Hepatic Portal Circulation:**
- Hepatic portal circulation is a system that carries blood from the gastrointestinal tract and spleen to the liver. This allows the liver to process nutrients and detoxify substances before they enter the systemic circulation.

2. **Substances Absorbed in the Intestine:**
- When food is digested, various nutrients are absorbed in the intestines. Commonly absorbed substances include amino acids, glucose, and fructose, which enter the hepatic portal circulation.

3. **Fatty Acids and Glycerol Absorption:**
- Unlike amino acids and sugars, fatty acids and glycerol are absorbed differently. They do not enter the blood directly; instead, they are absorbed into the lymphatic system.

4. **Lymphatic System and Lacteals:**
- The absorption of fatty acids and glycerol occurs through specialized lymphatic vessels called lacteals, which are located in the intestinal villi. These substances are then transported via the lymphatic system, bypassing the hepatic portal circulation.

5. **Conclusion:**
- Therefore, the substances that are not related to the hepatic portal circulation are fatty acids and glycerol, as they are absorbed into the lymphatic system rather than the portal vein leading to the liver.

**Final Answer:**
- The substances which are not related to hepatic portal circulation are **fatty acids and glycerol**.

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