Adversely affected organs with charcterised by signs & symptoms are affected by

Answer

To answer the question "Adversely affected organs characterized by signs & symptoms are affected by ___", we can follow these steps:

### Step 1: Understand the Question
The question is asking about the cause of adverse effects on organs, which are indicated by specific signs and symptoms.

### Step 2: Identify the Key Terms
- **Adversely affected organs**: This refers to organs in the body that are not functioning properly.
- **Signs and symptoms**: These are indicators of a problem; signs are observable by others, while symptoms are felt by the individual.

### Step 3: Consider Possible Causes
The question implies that there is a specific cause leading to the adverse effects on these organs. Common causes of such issues include infections, injuries, or diseases.

### Step 4: Connect to the Concept of Disease
Among the possible causes, "disease" is a broad term that encompasses various conditions that can adversely affect organs. Diseases can lead to both signs (like swelling, redness) and symptoms (like pain, fatigue).

### Step 5: Formulate the Answer
Based on the analysis, the correct answer to fill in the blank is "disease". Diseases cause adverse effects on organs, which are characterized by specific signs and symptoms.

### Final Answer
Adversely affected organs characterized by signs & symptoms are affected by **disease**.

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