Toxin in malaria, which results chill & high fever in humans is :-

Answer

**Step-by-Step Solution:**

1. **Understanding Malaria**: Malaria is a disease caused by a parasite belonging to the genus *Plasmodium*. It is important to note that this parasite is transmitted to humans through the bite of infected female Anopheles mosquitoes.

2. **Transmission**: The transmission occurs when an infected female Anopheles mosquito bites a healthy human, introducing the *Plasmodium* parasite into the bloodstream.

3. **Target of the Parasite**: Once inside the human body, the *Plasmodium* parasite primarily infects red blood cells (RBCs). This is crucial in understanding the symptoms associated with malaria.

4. **Symptoms of Malaria**: The disease is characterized by symptoms such as chills and high fever. These symptoms are a direct result of the body's response to the infection.

5. **Cause of Fever and Chills**: The chills and high fever experienced during malaria are caused by the rupture of red blood cells. This rupture leads to the release of toxic substances into the bloodstream.

6. **Identifying the Toxin**: The specific toxic substance responsible for causing the chills and high fever in humans during malaria is known as **Hemozoin**. Hemozoin is a byproduct formed when the *Plasmodium* parasite digests hemoglobin from the red blood cells.

7. **Conclusion**: Therefore, the toxin in malaria that results in chills and high fever in humans is Hemozoin.

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