Biological response modifier which activate their immune system and help in destroying the tumor is :-

Answer

To answer the question regarding the biological response modifier that activates the immune system and helps in destroying tumors, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Biological Response Modifiers (BRMs)**:
- Biological response modifiers are substances that can enhance the body's immune response against cancer. They work by stimulating the immune system to recognize and destroy tumor cells.

**Hint**: BRMs are substances that boost the immune system's ability to fight cancer.

2. **Mechanism of Action**:
- BRMs trigger the immune system to act more effectively against tumors. This can be achieved by administering these substances in larger amounts, often through injection or infusion.

**Hint**: Think about how BRMs interact with the immune system to enhance its function.

3. **Types of Biological Response Modifiers**:
- There are various types of BRMs, including hematopoietic agents. Two notable examples are:
- Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)
- Granulocyte Colony Stimulating Factor (G-CSF)

**Hint**: Focus on the specific types of BRMs that are known to stimulate immune responses.

4. **Examples of BRMs**:
- GM-CSF is known as sargramostim, and G-CSF is known as filgrastim. These agents help increase the production of white blood cells, which are crucial for fighting infections and tumors.

**Hint**: Remember the names of these agents as they are key examples of BRMs.

5. **Application in Cancer Treatment**:
- BRMs can be used alone or in conjunction with other cancer treatments, such as chemotherapy, to enhance the overall effectiveness of the treatment.

**Hint**: Consider how BRMs can complement other cancer therapies.

### Final Answer:
The biological response modifiers that activate the immune system and help in destroying tumors are Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) and Granulocyte Colony Stimulating Factor (G-CSF).