Which point is incorrect about Myasthenia gravis disease :-

Options

A. Neuromuscular junction is affected
B. Auto-immune disorder
C. Secretion from nerve terminal is reduced
D. Can lead to fatigue, weakining and paralysis of skeletal muscle

Answer

To determine which point is incorrect about Myasthenia Gravis disease, we need to analyze the statements provided regarding the condition.

### Step-by-Step Solution:

1. **Understanding Myasthenia Gravis**:
- Myasthenia Gravis is an autoimmune disorder where the immune system produces antibodies that attack acetylcholine receptors at the neuromuscular junction. This leads to muscle weakness and fatigue.

2. **Evaluating the Options**:
- **Option 1: Neuromuscular junction defect**: This statement is correct. Myasthenia Gravis is indeed a defect at the neuromuscular junction due to the presence of antibodies against acetylcholine receptors.
- **Option 2: Autoimmune disorder**: This statement is also correct. Myasthenia Gravis is classified as an autoimmune disorder.
- **Option 3: Secretion from the nerve terminal is reduced**: This statement is partially incorrect. While the antibodies affect the receptors, they do not reduce the secretion of acetylcholine itself. The secretion remains normal, but the receptors are blocked or destroyed, preventing effective muscle contraction.
- **Option 4: Can lead to fatigue, weakening, and paralysis of the muscle**: This statement is correct. The condition leads to muscle fatigue and weakness due to the impaired transmission of signals at the neuromuscular junction.

3. **Identifying the Incorrect Point**:
- The incorrect point is the statement that "secretion from the nerve terminal is reduced." The secretion of acetylcholine is not reduced; rather, it is the receptors that are affected.

### Conclusion:
The incorrect point about Myasthenia Gravis disease is that "secretion from the nerve terminal is reduced."

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