Glucose will show mutarotation when solvent is :

Options

A. Acidic
B. Basic
C. Neutral
D. Amphiprotic

Answer

### Step-by-Step Solution:

1. **Understanding Mutarotation**:
- Mutarotation refers to the change in the optical rotation of a solution as it equilibrates between different anomeric forms of a carbohydrate. In the case of glucose, it can exist in two anomeric forms: alpha (α) and beta (β).

2. **Identifying Conditions for Mutarotation**:
- For mutarotation to occur, the solvent must allow for the conversion between these anomers. This typically involves the solvent being able to facilitate the interconversion process.

3. **Evaluating the Solvent Options**:
- **Acidic Solvent**: An acidic environment may not favor the equilibrium between the anomers as it can lead to protonation and affect the stability of the forms.
- **Basic Solvent**: A basic environment may also hinder the interconversion process due to deprotonation reactions.
- **Neutral Solvent**: A neutral solvent provides a balanced environment that allows glucose to equilibrate between its anomeric forms without interference from acidic or basic conditions.
- **Amphiprotic Solvent**: While amphiprotic solvents can donate and accept protons, they may not provide the stable environment needed for mutarotation.

4. **Conclusion**:
- Based on the analysis, glucose will show mutarotation when the solvent is **neutral**. Therefore, the correct answer is that glucose will show mutarotation when the solvent is neutral.

### Final Answer:
Glucose will show mutarotation when the solvent is **neutral**.

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