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It is necessary to control pH during the...

It is necessary to control pH during the reaction of carbonyl compounds with ammonia derivatives. Explain.

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This reaction is catalysed by acids. In this nm H+ ion attacks on O-atom of carbonyl I results fa protonation . Which creates positive charge on the C-atom by resonence and makes corldition for . the attack of weak nucleophile (ammonia derivatives) as :

Now if medium is very acidic then ammonia derivatives forming their salts and if mediumlis weakly acidic then again protonation of carbonyl gp will not take place and hence for the reactiod we areito control pH during the addition of reaction (around 3.5)
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