In the following questions, sentences are given with blanks to be filled in with an appropriate word(s). Four alternatives are suggested for each question. Choose the correct alternative out of the four as your answer.
_____ following all the instructions closely, he missed out an important guideline.

Options

A. Instead of
B. Although
C. In spite of
D. Otherwise

Answer

C

Explanation

In spite of (Idiom) : despite, Without being prevented by, not stopped by
Here, In spite of ls the right usage.