Home
Class 12
BIOLOGY
In sickle cell anaemia, the sequence of ...

In sickle cell anaemia, the sequence of amino acid from first to seventh position of `beta`-chain of haemoglobin S (HbS) is

A

His, Leu, Thr, Pro, Glu, Val, Val

B

Val, His, Leu, Thr,Pro,Val, Glu

C

Thr, His Pro, Val, Pro, Val, Glu

D

Glu, His, Leu, Pro, Val, Glu, Glu

Text Solution

Verified by Experts

The correct Answer is:
D
Promotional Banner

Similar Questions

Explore conceptually related problems

In sickle cell anaemia, there is change in amino acid in beta chain at position

Sickle-cell anemia is caused due to the substitution of : 1. Valine by glutamic acid at sixth position of alpha chain of heamoglobin 2. Valine by glutamic acid at sixth position of beta chain of haemoglobin 3. glutamic acid by valine at sixth position of alpha chain of haemoglobin 4. glutamic acid by valine at sixth position of beta chain of haemoglobin

How many amino acids are there in the alpha chain of haemoglobin?

In sickle cell anaemia glutamic acid is replaced by valine Which one of the following triplets codes for valine ?

Study the following carefully and explain why mutation (A) did not cause any sickle cell anemia in spite of change in the molecular structure of the gene which codes for Haemoglobin, when as a similar mutation (B) did. (The question is based on properties of the genetic code. c= codon, a = amino acid, Hb = Haemoglobin) Codons for Hb: C_1 - C_2 -C_3 -C_4 - C_5 -G AA -GAA- C_8 ... Amino acids in Hb : a_1-a_2-a_3-a_4-a_5 - Glutamic acid- Glutamic acid - a_8 ...... (Normal Haemoglobin ) Mutation (A) : C_1 -C_2 - C_3 -C_4 -C_5-GAG-"GAA"-C_8...... a_1-a_2 - a_3-a_4-a_5 -Glutamic acid -Glutamic acid - a_8 .... (Normal Haemoglobin ) Mutation (B) : C_1 -C_2 - C_3 -C_4 -C_5-GAG-"GAA"-C_8...... a_1-a_2 - a_3-a_4-a_5 -Valine-Glutamic acid - a_8 .... (Sickle cell Haemoglobin )

[A]: Genetic disorder, sickle cell anaemia is common in new born babies· [R]: It is caused by heterozygosity for allele Hbc, producing a single amino acid substitution in the a-chain of the Haemoglobin determined by allele Hb^A

First scientist to find out amino acid sequence of a protein was

[A]: Sickle-cell anaemia is a genetically de- termined disorder affecting many new born babies. [R]: It is caused by heterozygosity for allele Hb^c , producing a single amino acid substitu- tion in the a-chain of the normal haemoglo- bin molecule determined by allele Hb^A .

After the addition of the last amino acid to a growing polypeptide chain during the process of protein synthesis, one of the termination codons reaches the appropriate site on the ribosomal surface and then the following envents take place (i) Release of t-RNA molecule from the ribosome. (ii) Dislodging of polypeptide chain from the t-RNA (iii) Dissociation of ribosomes into large and small subunits. The correct sequence of these events:

There is only one possible sequence of amino acids when deduced from a given set nucleotides. But multiple nucleotides sequence can be deduced from a single amino acid sequence. Explain this phenomena.