Mature Graafian follicle is generally present in the ovary of a healthy human female around.

Options

A. 5-8 days of menstrual cycle.
B. 11-17 days of menstrual cycle.
C. 18-23 days of menstrual cycle
D. 24-28 days of menstrual cycle.

Explanation

To answer the question regarding when the mature Graafian follicle is generally present in the ovary of a healthy human female, we can break down the menstrual cycle into its phases and identify the relevant time frame.

### Step-by-Step Solution:

1. **Understanding the Menstrual Cycle**: The menstrual cycle is a series of natural changes in hormone production and the structure of the uterus and ovaries. It typically lasts about 28 days but can vary among individuals.

2. **Phases of the Menstrual Cycle**:
- **Menstrual Phase (Days 1-5)**: This phase involves heavy blood flow, known as menses.
- **Follicular Phase (Days 6-17)**: This phase begins after menstruation and involves the maturation of follicles in the ovaries. The follicles grow and develop during this time.
- **Ovulatory Phase (Around Day 14)**: This is the critical phase where the mature Graafian follicle ruptures and releases an egg (ovulation). This typically occurs around the 14th day of the cycle.
- **Luteal Phase (Days 18-28)**: Following ovulation, the ruptured follicle transforms into the corpus luteum, which secretes hormones like progesterone.

3. **Identifying the Presence of Mature Graafian Follicle**: The mature Graafian follicle is generally present just before ovulation, which is around the 14th day of the menstrual cycle. Therefore, it is primarily present during the follicular phase, particularly from around day 11 to day 14.

4. **Conclusion**: The mature Graafian follicle is generally present in the ovary of a healthy human female around the time of ovulation, specifically around day 14 of the menstrual cycle.

### Final Answer:
The mature Graafian follicle is generally present in the ovary of a healthy human female around day 14 of the menstrual cycle.

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