What is the genetic disorder in which an individual has an overall masculine development, Gynaecomastia, and is sterile ?

Options

A. Turner's syndrome
B. Klinefelter's syndrome
C. Down's syndrome
D. Edward syndrome

Explanation

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks for a genetic disorder characterized by overall masculine development, gynaecomastia, and sterility.

2. **Analyzing the Options**: The options provided are:
- A) Turner syndrome
- B) Klinefelter syndrome
- C) Down syndrome
- D) Edwards syndrome

3. **Identifying Key Features**:
- **Overall Masculine Development**: This suggests that the individual has male physical characteristics.
- **Gynaecomastia**: This is the development of breast tissue in males, which is often associated with hormonal imbalances.
- **Sterility**: This indicates that the individual is unable to reproduce.

4. **Evaluating Each Option**:
- **Turner Syndrome**: This condition affects females and is characterized by the absence of one X chromosome. It does not fit the masculine development aspect.
- **Klinefelter Syndrome**: This condition affects males and is characterized by the presence of an extra X chromosome (XXY). It is associated with masculine development, gynaecomastia, and sterility.
- **Down Syndrome**: This is a genetic disorder caused by the presence of an extra chromosome 21. It does not match the symptoms described.
- **Edwards Syndrome**: This is a condition caused by an extra chromosome 18 and is associated with severe developmental issues, not specifically with masculine traits or gynaecomastia.

5. **Conclusion**: Based on the analysis, Klinefelter syndrome (Option B) is the correct answer as it aligns with all the symptoms described in the question.

**Final Answer**: The genetic disorder in which an individual has overall masculine development, gynaecomastia, and is sterile is Klinefelter syndrome.

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