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Assertion (A): Sickle cell anaemia is an...

Assertion (A): Sickle cell anaemia is an example of point mutation.
Reason ( R): It is caused by addition or deletion of nitrogenous bases in the DNA or mRNA.

A

Both assertion (A) and reason ( R) are true and reason ( R) is the correct explanation of assertion (A).

B

Both assertion (A) and reason ( R) are true but reason ( R) is not the correct explanation of assertion (A).

C

Assertion (A) is true but reason ( R) is false.

D

Assertion (A) is false but reason ( R) is true.

Text Solution

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The correct Answer is:
**Step-by-Step Solution:** 1. **Understanding the Assertion (A)**: The assertion states that "Sickle cell anaemia is an example of point mutation." - A point mutation refers to a change in a single nucleotide base pair in DNA. Sickle cell anaemia is indeed caused by a single nucleotide substitution in the beta-globin gene. 2. **Understanding the Reason (R)**: The reason states that "It is caused by addition or deletion of nitrogenous bases in the DNA or mRNA." - This statement is incorrect in the context of sickle cell anaemia. Sickle cell anaemia is specifically caused by a substitution mutation (the replacement of one base with another), not by the addition or deletion of bases. 3. **Evaluating the Relationship**: We need to determine if both the assertion and reason are correct, and if the reason correctly explains the assertion. - The assertion is correct (sickle cell anaemia is a point mutation). - The reason is incorrect (it does not involve addition or deletion). 4. **Conclusion**: Based on the evaluation, the correct option is that the assertion is correct, but the reason is wrong. **Final Answer**: The assertion is correct, but the reason is wrong. ---

**Step-by-Step Solution:** 1. **Understanding the Assertion (A)**: The assertion states that "Sickle cell anaemia is an example of point mutation." - A point mutation refers to a change in a single nucleotide base pair in DNA. Sickle cell anaemia is indeed caused by a single nucleotide substitution in the beta-globin gene. 2. **Understanding the Reason (R)**: The reason states that "It is caused by addition or deletion of nitrogenous bases in the DNA or mRNA." - This statement is incorrect in the context of sickle cell anaemia. Sickle cell anaemia is specifically caused by a substitution mutation (the replacement of one base with another), not by the addition or deletion of bases. ...
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